Category: Safe and Effective

Safe And Effective ®

@EricTopol

There needs to be truth-telling about the reduced protection of mRNA vaccines vs symptomatic Delta infections. It was 95% pre-Delta. Many are claiming it’s still ~80%.

It isn’t. 50-60% is best estimate from all sources (not US, since we don’t have the data) …

Look at Israel’s Delta case surge, a model country for vaccination, >15 per cent points more of total population vaccinated than the US. That, in itself, tells us about the reduction of protection of mRNA vaccines vs cases/spread.

Bumped for this update.

Maybe Geert Vanden Bossche knew what he was talking about, after all.

Safe And Effective ®

Dr. Sebastian Rushworth;

A study recently published in the Lancet Healthy Longevity sought to estimate the extent to which drug trials underestimate side effects. It was funded by the UK Medical Research Council and the Wellcome Trust. The study chose as its particular focus people being treated for high blood pressure with a certain class of blood pressure lowering drugs known as RAAS blockers (which includes all drugs with names ending in -pril and all drugs with names ending in -sartan). The advantage with looking at this particular class of drugs is that there are a ton of trials. Every major pharmaceutical company has its own RAAS-blocker. It should therefore be possible to draw relatively broad conclusions about the results – whatever they show, they apply to the entire pharmaceutical industry, not just to a few specific companies. It’s also reasonable to think that the results apply to other classes of drugs too – there’s no reason to think trials of RAAS-blockers have been done differently than trials of other drug classes.

What the study sought to do more specifically was compare the rate of serious adverse events in clinical trials of RAAS-blockers with the rate observed in the real world. A serious adverse event is any event that is potentially life threatening or that results in death, hospitalization or lasting disability. If a trial has been designed in such a way that it is representative of reality, then the rate of serious adverse events in the trial should largely mirror that seen in the real world.

110 trials of RAAS-blockers were identified by the researchers. Of these, 11 were specifically designed to look at older people (i.e. didn’t recruit anyone under the age of 60). The data on serious adverse events from these 110 trials was extracted and compared to real world data on deaths and hospitalizations taken from a UK government funded database of 55,000 people living in Wales, who were being treated with RAAS-blockers. Deaths and hospitalizations are not exactly the same thing as serious adverse events (which as mentioned above also include “life threatening events”, and could for example include someone who is treated in an emergency department after a fall but not admitted to the hospital), but they’re close enough to allow a reasonable comparison.

So, what were the results?

Safe And Effective ®

Let me begin by stressing that I’m not an anti-vaxxer — not by any stretch of the imagination. And every time I use this post title, I want you to remember that.

It’s not just that I’ve had childhood vaccines and a couple of tetanus shots, but vaccines remain the most important step forward for the health and longevity of purebred companion dogs (of which I am a breeder) of the last 100 years. Vaccines are a way of life here, and like many of you in the agriculture industry, I routinely administer them myself. They protect against the horrors of parvovirus and distemper. Diseases that once wiped out a lifetime of work in a week are no longer a threat, and for that I am grateful.

That said…

Holy Hell, failures like this have a way of making you sit up and pay attention.

Something strange started happening to calves in Europe in 2007: Horrific blood clotting issues & depletion of bone marrow Read how in 2010, under pressure, Pf!zer finally withdrew the BVD vacc!ne linked to Bleeding Calf Syndrome

From 2011: Vaccine linked to ‘bleeding calf syndrome’

Bleeding calf syndrome (bovine neonatal pancytopenia or BNP) affects new born calves resulting in low blood cell counts and depletion of the bone marrow. It first emerged in 2007 and a serious number of cases are reported each year. In affected calves, bone marrow cells which produce platelets are also destroyed. Consequently the calves’ blood does not clot and they appear to bleed through undamaged skin. There is evidence that BNP is linked to the use of a particular vaccine against “Bovine viral diarrhea virus” (BVDV). […]

Prof Till Rümenapf from Justus-Liebig-Universität Giessen commented that, “Alloantibodies (antibodies generated by one individual of a species against another of the same species) are produced by the mother if she has different MHC I than the bovine cells used to grow the vaccine. These do not harm the mother. However if her calf has the same MHC I as the vaccine production cells, the antibodies in her colostrum will destroy the calf’s cells, including those of the bone marrow. Destruction of megakaryocytes results in the calf being unable to produce platelets and consequently its blood cannot coagulate.”

I can guarantee no one at Pfizer saw that coming. Let’s hope they learned something from it.

Navigation