Safe and Effective®

Stanford Medicine study shows why mRNA COVID-19 vaccine can cause myocarditis

Stanford Medicine investigators have unearthed the biological process by which mRNA-based vaccines for COVID-19 can cause heart damage in some young men and adolescents — and they’ve shown a possible route to reducing its likelihood.

Using advanced but now common lab technologies, along with published data from vaccinated individuals, the researchers identified a two-step sequence in which these vaccines activate a certain type of immune cell, in turn riling up another type of immune cell. The resulting inflammatory activity directly injures heart muscle cells, while triggering further inflammatory damage.

@AnwaltUlbrich (translated from German);

Six years after the global rollout of mRNA vaccines, established science is finally admitting what affected individuals, critical physicians, and independent researchers have been saying for a long time: the mechanism of action of these vaccines was fundamentally misunderstood from the very beginning. Anyone who said so until now was considered an outsider. Today, it is featured in Nature Biotechnology.

The Bombshell from Mount Sinai

On April 29, 2026, researchers led by Prof. Brian D. Brown, Director of the Icahn Genomics Institute at Mount Sinai Hospital in New York, published the paper

“mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression” (Marks et al., DOI: 10.1038/s41587-026-03099-z).

The senior author himself summarizes the implications with a candor that is sure to raise eyebrows:

“This study fundamentally changes how we think mRNA vaccines work.”

And elsewhere: “That was unexpected.” — six years after billions of doses administered to humans. […]

The researchers documented:

1. massive T-cell infiltration into liver tissue (around 1,100 CD8 T cells per mm²)
2. significantly elevated liver values ALT and AST — the classic clinical markers for liver cell damage
3. a clear increase in apoptotic cells (Caspase-3 cleavage)

The authors state in the discussion with remarkable directness:

“It is possible, however, that muscle or hepatocyte damage may also occur with RNA-LNP treatments in multi-dose or CAR-T cell applications, which are difficult to detect but limit the therapeutic index by pushing up the dose ceiling.”

In plain English: Damage can occur — it’s just hard to find. This is something fundamentally different from the formula repeated for years: “safe and effective.”

And more. Via Tim Pool.

33 Replies to “Safe and Effective®”

  1. Six years after the global rollout of mRNA vaccines, established science is finally admitting what affected individuals, critical physicians, and independent researchers have been saying for a long time: the mechanism of action of these vaccines was fundamentally misunderstood from the very beginning. Anyone who said so until now was considered an outsider. Today, it is featured in Nature Biotechnology.

    It’s good that they understand the mechanism better, but this is a rather inflammatory take.

      1. The best thing you can do with opinions you don’t want to hear is lash out with insults. Always works.

        1. What you take as insults are simply objective observations. Go get another booster, hotshot.

    1. The first mandates requiring COVID-19 vaccination began appearing in mid-2021, several months AFTER the vaccines were authorized and initial safety signals (like myocarditis) were identified in April 2021.

      So tell the people who have damaged hearts and the family of those died suddenly that the Tim Pool is being too inflammatory.

      1. The “inflammatory” part of the quote is the where the author tries to make it a story about the establishment versus independent researchers regarding the mechanism causing myocarditis.

        If you read the story carefully, you’ll find no evidence for that. Rather it quickly devolves into “How dare scientists release a vaccine whose mechanisms and consequences that they did not understand in complete detail?”

        But of course no medical treatment is ever understand in complete detail in the beginning, and by demanding such a high standard, no treatment would ever be released.

        1. You could always simplify your defense against this newfound research by blaming Trump’s “Warp Speed” short cutting of all those cumbersome FDA and CDC guardrails requiring drug trials and … TIME … to properly analyze vaccines.

          Of course “Warp Speed” is the child of “EMERGENCY!!!” … the same word used to summarily strip every American of their Constitutional… and Human … Rights … because COVID.

          Now … can we move on to the ORIGIN of this manmade virus? How it was weaponized and deployed to STOP Trump’s runaway success with the American economy … and how it was the FINAL SOLUTION in the Dem’s bag of insurance policies?

          1. I’m not defending this new research. It needs no defense.

            So far as addressing the politics behind the COVID vaccine rollouts, have at ‘er. Knock yourself out.

          2. COVID was ALL political … so political that the First Amendment needed to be cancelled … and anyone who dared to claim its protections were summarily cancelled. Yeah, politics was COVID … and COVID was politics. And the vaccine was unvetted, dangerous, junk. $Billions in junk science.

            “Public Health” was used to STRIP Americans of their fundamental Rights …

            In the same way …

            “National Security” has been used to strip our Rights away.

            Don’t pretend this isn’t political

          3. COVID was ALL political

            No it wasn’t. There was also the purely scientific question of how safe and effective the vaccines were. I think the COVID anti-vaxxers are wrong about that question, and I regularly debate them on it.

        2. By all means, continue ignoring the extraordinary measures taken to ensure that every vaccine safeguard was leapfrogged in the name of “emergency authorization”, despite circumstantial evidence that less dangerous treatments seemed effective, despite bodies stubbornly failing to pile up in the streets.

          “How dare scientists release a vaccine whose mechanisms and consequences that they did not understand in complete detail?” Well, that’s kind of what they’re supposed to do. And would have done, had there not been extraordinary pressure brought to bypass all of that.

          1. By all means, list those safeguards that were “leapfrogged”.

            The vaccine approval process took every step required of every vaccine. The process was expedited (which the CDC allows for), but not a single step was missed. You are regurgitating common myths passed around by the anti-vax crowd.

        1. That link discusses the period between December 2020 and January 2022, a 14-month stretch. There were many reports after that of complications after vaccination.

          All of the provincial health authorities across Canada daily published charts showing the rates of infection, hospitalization, ICU, and death for both vaccinated and unvaccinated. The numbers first looked bad for the unvaxxed, but then they started to merge and once the vaxxed were being hospitalized or ICU’d or dead at higher rates than the unvaxxed, the data abruptly stopped. No more charts, no more numbers. Why was that??

          As well, the manipulation of the numbers was blatantly dishonest. A vaxxed person was considered unvaxxed for two weeks after the first shot. Some of those people sickened and/or died during that period, and made the unvaxxed hospitalization and death rates look much worse than they actually were.

          1. The numbers first looked bad for the unvaxxed, but then they started to merge and once the vaxxed were being hospitalized or ICU’d or dead at higher rates than the unvaxxed, the data abruptly stopped.

            That didn’t actually happen. It’s a myth that the anti-vaxx community tells to itself. Feel free to prove me wrong, citing specific instances where that happened, including links.

        2. Did they die at a greater or lesser rate than RATS WITH ENORMOUS WANGDONGERY??

          (Oh, come on. You knew it was coming)

          Relying solely on “peer-reviewed studies” for your specious arguments only works if the entire edifice of peer review isn’t thoroughly corrupted by self-dealing and destructive ideology. Which it is. Garbage in, garbage out.

          1. I rely on peer-reviewed studies because it’s the best we have. By contrast, the anti-vax crowd seems to rely on YouTube influencers.

  2. Well colour me shocked and surprised. When the true damage inflicted by this ‘experimental’ injection is finally revealed who is going to be held accountable? Perhaps the better question is how are we going to hold those responsible to account. From Fauci and his co-conspirators in the gain of function experiments, through to the government health authorities, the medical professionals who fell into step, the media that spread the lie, and the companies that threatened termination for non-compliance, who will be held accountable? Do we just sit back and accept the “Ha…Ha… We fooled you!” or do we demand a Nuremberg series of trials with criminal convictions and suitable incarceration and disbarments. I’m not holding my breath!

    1. It’s been known that the COVID vaccines could induce myocarditis since early 2021. There is nothing new about that. What is new here is an explanation for the mechanism behind it.

      But keep in mind that the COVID disease itself also induced myocarditis, and at a far greater rate and with more severe symptoms than the vaccines. By preventing or mitigating COVID, the vaccines may well have reduced one’s chances of getting myocarditis, although that hasn’t been definitively shown in the statistics.

      1. Well of course, there was no way to determine what caused myocarditis in the vaccinated. Just like there was no way to determine the cause of death in so many elderly who got “vaccinated” and died shortly thereafter. Like my mother-in-law for example…..two weeks after her “booster”, she died. No autopsy, of course.

        1. In principle, one can determine if the COVID vaccines reduced one’s chances of getting myocarditis during a COVID epidemic. But it requires large-scale statistical studies. Nothing can be determined from a single case, autopsy or no autopsy.

          1. That’s like saying … if we dug ONE hole to find mass genocided indigenous children
            … it would determine … nothing.

            So no holes will be dug.

    2. And the worst of it since no one has had any form of confession, apology, and there is still no transparency, they can do it to us again tomorrow and we can’t do a thing about it. That’s what gets to me. Certain people made a lot of money and satisfied their power lust and sadistic side. And they can do it again!

  3. I didn’t buy into the conspiracy that the clot shots were an effort to cull the population but I believe it now.

  4. Wow, it’s like most SDA readers got it right all along. Except mouthy boy here filling the comments with a pile of lies.

    1. It’s been known that the COVID vaccines could induce myocarditis since early 2021. There is nothing new about that. What is new here is an explanation for the mechanism behind it.

      But everytime there’s a story mentioning that COVID vaccines can induce myocarditis, COVID anti-vaxxers jump up and down like it’s some startling new admission that proves they were right all along. It’s very odd.

      1. Except some pro vaxers continued to say well past 2021 that myocarditis was not a problem and that myocarditis was caused by catching covid.

  5. The webs they weave.
    I read one article on J&J and AstraZeneca examining their efforts. Now I read this.
    They’re chasing their tails. They cannot determine efficacy of any of this shit with the spike protein.
    I’ll try to make this simple and brief.
    2014: Grants are given to find bat Corona virus and particularly virus that attaches to human ACE-2. They find one, study it, amp up function by adding furin cleavage site. Oops, it gets out.
    Must have vaccine, hurry hurry. Attenuate the spike protein by removing lab added furin cleavage site. Write it up. State there are other cleavage sites on spike of unknown propensity. Distribute attenuated spike, make vaccine, some RNA replicating some not, whatever. Bad things happen, deny deny deny. Studies ensued. All different types of problems with whatever type of shot but the MRNA type was obviously worse. Then one study amongst thousands finds a furin cleavage site in a different location on the spike.
    (The original path to ACE-2 attachment they were looking for in 2014)
    It had to be there, otherwise this Corona strain would not affect people. You see, they removed the lab added furin cleavage site, the gain of function, mentioned other unknown cleavage sites, and basically injected us with the wild type Corona.
    So, I’m basically beyond caring. In the name of modern medicine good people are willing to do very bad things to you. It’s a perversity I care not to indulge.

  6. ” … and they’ve shown a possible route to reducing its (heart damage) likelihood.”

    A “possible” route? How about a surefire route?

    DON’T TAKE THE WITCH PISS!!!

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