New Paper- Paul E Marik, Jose Iglesias, Joseph Varon, Pierre Kory- A scoping review of the pathophysiology of COVID-19
While enormous strides have been made in understanding the molecular pathways involved in patients infected with coronaviruses an overarching and comprehensive understanding of the pathogenesis of COVID-19 is lacking. Such an understanding is essential in the formulation of effective prophylactic and treatment strategies. Based on clinical, proteomic, and genomic studies as well as autopsy data severe COVID-19 disease can be considered to be the connection of three basic pathologic processes, namely a pulmonary macrophage activation syndrome with uncontrolled inflammation, a complement-mediated endothelialitis together with a procoagulant state with a thrombotic microangiopathy. In addition, platelet activation with the release of serotonin and the activation and degranulation of mast cells contributes to the hyper-inflammatory state. Auto-antibodies have been demonstrated in a large number of hospitalized patients which adds to the end-organ damage and pro-thrombotic state. This paper provides a clinical overview of the major pathogenetic mechanism leading to severe COVID-19 disease.
Some pretty nerdy stuff.
“Antiviral therapy is likely to be effective only during the viral replicative symptomatic phase.” An Alberta doctor recently described the treatment of Covid in ICU. Nearly all patients had been sick for over two weeks before being hospitalized, making treatment extraordinarily difficult. Therapeutic nihilism at its worst.
“Nearly all patients had been sick for over two weeks before being hospitalized, making treatment extraordinarily difficult.”
Yep. “Stay at home until you’re sick enough to come to the hospital” ain’t much of a treatment.
Joseph Varon? Isn’t he the guy who shouldn’t believe his lyin’ eyes?
Utter bull.
It is not necessary to know a damn thing about the disease and how it progresses.
If you find something that stops it.
You do what works.
This is more intellectual masturbation.
We found things that worked against past plagues, no one knew why they worked but they survived..
Now that said,I suspect there is very good information as to how Covid/SARS-2 kills people,as it was designed at great expense to us taxpayers.
And everyday we learn how treatments for SARS-1 work just as well on SARS-2.
This is beyond incompetence.
It progresses and kills the same way influenza does. Not that anyone really gives a shit.
This is interesting: “Although patients may remain Polymerase Chain reaction (PCR) positive for up to 70 days, culturable virus is rarely detected after the 14th day of symptoms.” PCR positive for 70 days? Does this mean that for 2 months after infection a person who is given the PCR test would likely be considered a “case” even though already cured?
Yes, that is what that means.
I’m just guessing here, but Culturable virus implies to me that it is virus capable of replicating or active virus. The pcr test cannot discern between active or dead virus or between whole virus or fragments of virus so the test may appear positive.
Nerdy indeed, but the huge ignored gorilla in the living room is still that the Wuhan flu is no more fearsome than previous ones.
Every pundit should pound it – “Covid-19 is about average as flus go.”
The short answer is TPTB and the so-called “experts” are barking up the wrong tree with these non-sterilizing clot-shots. What is making people sick and killing some of them is not the virus itself, but their immune system’s reaction to the presence of said virus. Instead of going after the virus itself, which was always going to be problematic anyway (ADE, OAS, VEI), they should focus on treating the cascading immune dysfunction that happens in some patients, and trying to prevent its onset in all infected individuals. Their response to date has been a spectacular failure.
They don’t even try. The prescription is stay home until you get very very sick and then we’ll put you on a ventilator. That’s not a treatment.
Dr. Marik also does treatment. There is a comprehensive treatment protocol in a document online at evms.edu
Near 30 page pdf setting out the stages of the infection and the treatments appropriate to that stage.
But it comes down to Vitamin D and Vitamin C *beforehand* can have the greatest effect on the outcome
Francisco: I think you missed a key sentence.
“COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-19 is probably amongst the most complex of medical conditions known to medical science. ”
I listen to the FLCCC weekly updates and this is something that Dr Marik highlights, this and that you so not want to get covoid, and that since covid has three phases, it is important that the patient be treated with the right medication, at the right dosage, for the right amount of time for each phase.
Of course, most of us have heard Dr. Robert Malone, the inventor of the mRNA platform assert that the spike is cytotoxic, in and of itself. I came across this in the paper but I don’t have the ability to weigh its significance:
“Zuo et al.158 reported that 52% of patients hospitalized with COVID-19 had anti-phospholipid antibodies.158 These antibodies contribute to the profound pro-thrombotic state of severe COVID-19 infection. Both COVID-19 infection as well as spike protein–producing vaccines are associated with anti-platelet antibodies, thrombocytopenia, and a profound procoagulant state.159–161”
So far the vaccines only affect two of those pathologic processes, the pulmonary macrophage and the thrombotic. We’ll know more at some point in the future.
II think we are looking at this wrong. From the beginning the message has been to ” Protect the Healthcare system”. The vaccine only assists in lessening the need to use the system, that is it’s purpose, freely admitted. We are the virus, not covid.