Video — Miracles don’t exist in biology, mechanisms do. GLP1 medications (Ozempic, Wegovy, Mounjaro, Zepbound) are no exception. And every time you override a biological system that took two million years to evolve, you are making a trade. Every trade has an invoice.
Adding chemicals to your body is probably always hit or miss.
Weight loss should be fairly simple (i.e. no need for injections). Reduce input, increase output, be patient.
Side effects galore with a lot of recent treatments. Informed consent (though most people are idiots)!
Don’t hide the downside from safety studies.
I think RFK, Jr, with his team, are on the right track!
“I think RFK, Jr, with his team, are on the right track!”
I have high hopes for him too. Might pan out. Good comment.
Exercise to keep healthy especially your heart. Respect genetics. Be satisfied and expect that not everyone can have a body like Twiggy.
Excellent summary.
My endocrinologist has put me on Ozempic and then on Mounjaro. To be blunt, Ozempic made me shit the bed. Rather than slowing digestion it sped it up. This was especially true when I would eat fried foods like fried calamari. The drug didn’t respond well to those foods. I stopped taking it.
My Endo. was prescribing these drugs primarily for blood sugar control. So she next prescribed Mounjaro (5mg) which brought my GI tract to a screeching halt. I went from being quite regular to bloated and not pooping for days. Too unnatural, too awful … so I stopped it. However … Ozempic had done little to nothing to improve my blood sugar … but Mounjaro dropped it like a stone such that I had to cut my insulin use by 75%!
So my Endo. suggested I try 2.5mg of Mounjaro … which helped with the symptom of bloating and slow movements, but then gave me reflux (which I’ve never had in my life). But the lower dose still dropped my blood sugar dramatically. As much as I wanted Mounjaro to work for me … I don’t like screwing with Mother Nature and figured insulin alone is simply a replacement for the natural insulin my body no longer makes -vs- some new interruptive drug that interferes with natural million-year-old biological functions.
PS … I was directed to STOP Mounjaro two weeks prior to my recent hip replacement surgery. Now I learned the reason why.
I was put on Ozympic which did absolutely nothing for me even at max dose other than make me feel nauseous. I’m fighting genetics and a stressful job but those are not good enough excuses. I have become somewhat sedentary which puts me in a death spiral. Less activity means more weight means less activity. I try to stay as active as possible but for six months out of the year it’s cold icy and dark here. More excuses. I am not thrilled with my physique or health so I decided to try Monjero. So far so good. I figure I’ll die from the weight or the Monjero. It is absolutely no fun being overweight. I am the invisible pariah wherever I go so I don’t go anywhere anymore. I’ll take what modern science can give me. I have been suggested to gastric bypass surgery but I scoffed at that. Way too many problems and I don’t see myself as that bad. I know that it’s genetics that I am mostly fighting because I never eat out, don’t drink and don’t smoke and I can and do buy only the best of foods. Carbohydrates are my drug like many others. I can tell now who is addicted to carbs. Same MO with all of us.
I went through the step up with Mounjaro with my only side effect being occasional nausea that made me eat less (which helps in the long run). My appetite is way down now, and I’ve lost ~40lbs over the last 9 months. I have bad knees and shoulders (cause of current size, not a result of,) so increased exercise usually results in injury resulting in cessation of mobility and exercise, so the drug is working wonderfully for me. I’ve never had insulin issues, ensure I take my other meds and vitamins daily, and am a regular blood donor (search “blood donor heart attack risk” to see why).
The step-up period is vital to determining if it can be a viable option. I’m maintaining a 10mg dose and have had to take in or replace half the pants in my wardrobe.
I would like to thank you and Kenji for noting your’ personal journeys with this treatment.
C.Minor … truth be told, I consider Mounjaro a MIRACLE drug. My pancreas produces ZERO insulin … yet with Mounjaro I could almost take NO insulin, because it neutralized my sugars THAT much. Don’t know how it does it, but it is remarkable and REAL. I did get some appetite suppressant which goes by almost unnoticeable to me … until I suddenly realize I’m not snacking anymore and have no desire to.
Congrats on your remarkable weight loss. Just curious, are you on 5mg or 2.5mg?
I started at 2.5, went through 5 and 7.5 (a month or more at each level) and am now steady-state at 10mg for over 3 months. Apparently, depending on body mass, up to 15mg can be a dosage. I was getting regular blood tests for something else during the ramp up, and my doctor approved all changes after ensuring there weren’t systemic changes that I didn’t notice.
Agreed on the snacking. I had a week at an all-inclusive resort in December and came home the same weight as when I left. 2 meals a day (and I don’t want as large of portions for them) are my normal, now.
If I recall aright both Ozempic and Mounjaro were originally released as diabetes treatments. That’s what they were meant to do, the weight loss is essentially a side effect.
And, ironically, Ozempic cannot be prescribed for weight loss in Alberta and Mounjaro cannot be prescribed for diabetes (according to my doctor).
Wow. Speaking for myself that’s insane. After my very first Mounjaro injection … my blood sugar immediately plunged to life threatening levels … below 60. I was panic eating gobs of honey and bread … which ironically undermined whatever weight loss effect it was having. I quickly figured out how to balance: eating, Mounjaro, and insulin. Using barely any insulin.
(((And every time you override a biological system that took two million years to evolve, you are making a trade. Every trade has an invoice.)))
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Hello Vegans.
Seems like vegans are evolving into cows
Or evolving from cows….at least many of them I have seen.
From WaterBuffalo!
Well, when one has gone through a few rough(age) years, it shouldn’t be surprising if some are cowed by the experience…
Vegans like to pretend otherwise, but historically deliberately eating only plants was considered an asceticism. Like scourging yourself, or excessive fasting etc.
It isn’t supposed to be good for you, long term. It’s supposed to hurt. That was the point of doing it.
Evolution is just another failed belief.
If you are taking (or have taken in the past) a number of different pharmaceuticals, ask your doctor about your kidney function at your next physical.
I was born in the early 60’s.
There wasn’t a lot of fat people then or in the 70’s.
Even in to the 80’s.
That’s true. I’m from the mid 60s. But my Italian family was, well, rotund overall!
225 four years ago. Doc said, try these drugs, Instead, went keto. Lots and lots of little ribeye steaks, steak tacos with cheeses and onions and peppers, eggs – lots of eggs – chicken, seafood, pork chops – the lack of carbs evened out my own insulin spikes, so no more food cravings, now down to 155.
Those drugs make me nervous. Try keto instead.