UCLA chemists have discovered a major flaw in a fundamental rule of organic chemistry that has held for 100 years. They say it’s time to rewrite the textbooks.
Organic molecules, which are primarily made of carbon, have specific shapes and arrangements of atoms. Molecules called olefins contain double bonds, or alkenes, between two carbon atoms. Typically, these atoms and their attached groups lie in the same 3D plane, and deviations from this structure are rare.
The rule being questioned, known as Bredt’s rule, was established in 1924. It asserts that molecules cannot have a double bond at the “bridgehead” position—the junction of a bridged bicyclic molecule—because this position would distort the geometry of the double bond. Bredt’s rule has constrained the design of synthetic molecules by preventing chemists from creating certain structures. Since olefins play a critical role in pharmaceutical research, Bredt’s rule has limited the types of molecules that scientists could envision, potentially holding back innovations in drug discovery.
“potentially holding back innovations in drug discovery.” Better drugs, maybe, but, and this may seem counter-intuitive to many, more drugs may be a bad thing. I prefer a better diet instead of the possibility of more drugs, but a new discovery is cool none the less.
Has the work been replicated?
Same way, in 100 yrs or so we will find out that all covid ‘vaccines’ were scientifically speaking – POISON.
We only have to sit tight, relax and wait. Just don’t hold your breath.
Now, we cook!
Big Pharma are as giddy as a little girl
However, Big Pharma is STILL committed to a “Net Zero” operation by 2035
Lots of things put in place around that time are lies.
Expect more of this.
Hard to trust a report about “science” when it contains a glaring error like this: “….lie in the same 3D plane” .
Reminds me of the time a co-worker asked me how to convert metres to hectares.
Hmmm … by simple definition a plane is 2d … not 3d, eh? Kinda sums up the knowledge of “science writers” in the media